Enzyan

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Why Choose Us?

Passion for biocatalysis has driven Enzyan from the start. Building on decades of expertise from the University of Graz and leading institutions across Europe and the USA, our team transforms deep scientific knowledge into impactful solutions.

Combining the strengths of organic synthesis and biology, we bridge the gap between biocatalytic innovation and synthetic chemistry needs. Our integrated service portfolio helps customers de-risk early-stage development and secure a competitive edge through exclusive, cutting-edge biocatalytic solutions supported by flexible project execution and a strong partner network.

Biocatalysis research request

Services

1. Early-Stage Ideation & Conceptualization

Not sure whether biocatalysis could be a fit for you? Or maybe you have an idea for a biocatalytic application, but you’re not sure if something like this has been done or can be done. We use our experience, expertise and network to help you identify opportunities and actions to implement enzyme-based solutions for your problem. We have seen many innovative application cases of biocatalysis across different industries and it’s very likely that there is one for you too. Get in touch with us to find out!

2. Enzyme Discovery

Finding the needle in a haystack. This is the heavy lifting we do in our enzyme discovery service. We take a deep dive into the state of the art and databases and rationally select enzymes from various classes based on the objective. We express and screen the biocatalysts in house to find the one that does what you want. Of course we also take care of assay development, analytics, material procurement and everything else that is needed. Aspects like patent literature and Nagoya protocol are also actively considered in the selection of enzymes in our screening panels. Our integrated service by experts thus helps you to minimize risk in this crucial first step on the way to a successful biocatalytic process.

3. Biocatalytic Route Scouting

Being chemists by training, we consider enzymes as biocatalysts that can enable reactions that are simply impossible to achieve with traditional synthetic chemistry. Their unmatched precision and selectivity allows biocatalysts to dramatically cut short existing chemical syntheses if used right. In fact, some biocatalysts are well compatible with common reagents and solvents, opening up opportunities for innovative hybrid “chemoenzymatic” routes. Our ability to recognize such opportunities helps our clients to stay ahead of competitors and upgrade their manufacturing processes to the next level.

4. Biocatalytic Cascade Design

We strongly believe that one of the greatest – and yet underutilized –  features of biocatalysts is their compatibility with each other. That’s why some of our team members were among the first ones to pioneer the field of in vitro biocatalytic cascades. Together with the innate precision of enzymes, combining several biotransformation steps to make a compound of choice in a single reactor operation becomes feasible. Not only this reduces the overall process time, costs and waste, but it also opens up new design options as, for example, unstable intermediates can be generated and consumed in situ in the blink of an eye. Take advantage of our expertise in this field to turn your manufacturing process into an innovative and efficient in vitro cell-free fermentation.

5. Optimization of Biocatalytic Reactions

Our biocatalytic reaction optimization service streamlines the development of efficient, scalable, and sustainable enzymatic processes. We specialize in tailoring reaction conditions to enhance enzyme performance, improve yield, and reduce byproducts. Whether you’re developing pharmaceuticals, fine chemicals, or specialty ingredients, our expert team uses a data-driven approach to identify optimal parameters pH, temperature, co-solvents, substrate loading, cofactor recycling systems and more. With cutting-edge analytical tools and deep biocatalysis expertise, we help accelerate your path from discovery to production.

6. Enzyme Engineering

Enzymes are tunable catalysts. As such they can be tailored to the conditions required to make for example an active pharmaceutical ingredient with high enantioselectivity or fragrance- and aroma compounds with high product titers. The iterative approach of directed evolution became a standard in the toolbox of biocatalytic process development. Based on the amount of information about a biocatalyst, manifold strategies, approaches and software tools are available to generate better biocatalyst variants. We offer an integrated service of variant library design, expression and screening including assay development to improve your biocatalyst of choice.

7. First upscales

We offer expert support in the critical transition from analytical-scale reactions (<1 mL) to preparative-scale (up to 100 mL), enabling early assessment of process scalability. Our service includes careful optimization of reaction conditions for larger volumes, along with optional initial investigations into product isolation and purification strategies. We focus on maintaining performance while addressing challenges like solubility, mixing, reagent addition and workup. Whether you’re preparing material for further testing or evaluating purification feasibility, our team ensures a smooth and data-rich scale-up phase laying the groundwork for future process development and scale-up success.

Biocatalysis research request

Testimonials

Anonymous customer
U.S.-based biotech startup

"Working with Enzyan has been a real asset to our progress. We were able to accelerate our timeline significantly, de-risk our process within a few months, and confidently move towards scale-up. The team was consistently communicative and professional throughout."

Eyal Akiva
Enzyme discovery specialist

"It was a pleasure collaborating with the Enzyan team on a previous project. I recommend their services”

Stefaan de Wildeman
B4Plastics

“What do you do when you need a world-new building block for polymers, that is only accessible via biocatalysis? And you lack the time for it? You outsource to a biocatalysis expert! Easily said! And easily done! By ENZYAN! Our new partner for these challenging innovation questions. ENZYAN did an intake of the process that was developed at TRL2, and estimated the time and effort to deliver the building block. B4PLASTICS took the offer, and perfectly on schedule, the building block was delivered. It is always intriguing to get the hands on building blocks that might be totally unique in the world, and to start polymer architecture with it, which – as a consequence – might also be completely new to the world. If that intriguing feeling can be shared between innovation partners, they become more than purely business partners. ENZYAN has now entered that inner circle of magic – where the innovation dreams become real samples and… products. Made by bio. Up for the next biocatalysis challenge!”

Anonymous customer
chemical manufacturing field

"Flexible, tailored solutions."

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We’ve had the chance to team up with amazing clients from all sorts of industries. Some of our customers prefer to remain anonymous and we fully respect and honor their privacy.

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