It does not happen every day that a new enzymatic reaction is discovered in nature. On paper this transformation may seem unlikely at first glance, but this study led by our co-founder Stefan demonstrates that it is very real and a great example of unparalleled efficiency of nature’s synthetic machinery.

Not only can biocatalysis provide access to complex natural product scaffolds like alkaloids, but it also enables their diversification in unique ways inaccessible to chemocatalysis.

And this is just the tip of the iceberg. There are many important targets not being explored because their synthetic route looks unlikely or difficult on paper. If you have such an example, reach out to us and let’s find a solution. The possibilities could surprise you.